Fatal cases of farmer's lung in a Canadian family. Probable new antigens, Penicillium brevicompactum and P olivicolor.
نویسندگان
چکیده
Three Canadian farmers, including a married couple and another close relative, died from progressive pulmonary fibrosis. Their histories and investigations were compatible with chronic farmer's lung (FL). Our environmental and immunologic studies indicate Penicillium brevicompactum and P olivicolor as probable new antigens of FL in a cool and dry climate.
منابع مشابه
Molecular identification of MPaB and MPaE genes from MPA gene cluster in new strain of Penicillium brevicompactum
Mycophenolic acid (MPA) is a fungal metabolite possessing antiviral, antifungal, antibacterial, antitumor and anti-psoriasis activities. It is being used as an immunosuppressive agent in kidney, heart and liver transplantation patients. In the presence of MPA, the proliferation of the B and T lymphocytes is inhibited. The MPaB and MPaE genes reside in a 25 kb gene cluster in t...
متن کاملEpidemiological study of farmer's lung in five districts of the French Doubs province.
The prevalence of farmer's lung was studied in five districts of the French Doubs province (Rougemont, Clerval, Levier, Montbenoît, Mouthe) on the basis of a medical and occupational questionnaire and serological studies for precipitins. Of the 1763 active farmers (response rate 69%) who participated in the study, 270 were suspected of having farmer's lung and divided, on the basis of clinical ...
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Penicillium brevicompactum and other isolates with the compact, complex conidiogenous apparatus typical of the species were sequenced in one ribosomal and two protein coding regions. The aligned DNA sequences were analyzed by maximum parsimony and the data from different loci were tested for compatibility using the partition homogeneity test. Analysis of each of the three loci revealed three cl...
متن کاملBrevianamides A and B Are Formed Only After Conidiation Has Begun in Solid Cultures of Penicillium brevicompactum.
In cultures of Penicillium brevicompactum grown on Czapek-Dox agar or on circles of dialysis membrane placed on Czapek-Dox agar, brevianamides A and B first appeared after conidiation had begun. The presence of these brevianamides imparted a yellow-green fluorescence to the penicilli and to the upper section of the conidiophores of actively conidiating cultures. Experiments with replacement cul...
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ورودعنوان ژورنال:
- Chest
دوره 111 1 شماره
صفحات -
تاریخ انتشار 1997